Anti-Monoamine Oxidase A/MAOA Antibody Picoband® fluoro647 Vervoeging

MAOA (Monoamine oxidase A), also known as AMINE OXIDASE (FLAVIN-CONTAINING) A, is an enzyme that in humans is encoded by the MAO-A gene. MAOA is an isozyme of monoamine oxidase which is also mapped on Xp11.3. MAOA degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the outer mitochondrial membrane. Mutation in MAOA results in monoamine oxidase deficiency, or Brunner syndrome. In humans, there is a 30-base repeat sequence repeated in one of several different numbers of times in the promoter region of the gene coding for MAOA. MAO-A levels in the brain as measured using positron emission tomography are elevated by an average of 34% in patients with major depressive disorder. Inhibition of MAOA prevented apoptosis, and serum starvation of cortical brain cells from Maoa-deficient mice resulted in reduced apoptosis compared with wildtype mice.

Amine oxidase [flavin-containing] A;1.4.3.4; Monoamine oxidase type A; MAO-A; MAOA

MAOA

4128

P21397

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human MAOA.

Heart, liver, duodenum, blood vessels and kidney.

Flow Cytometry

Neurodegenerative Disease, Neurology Process, Neuroscience, Neurotransmitter

Immunogen affinity purified.

Liquid

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

1. Breakefield, X. O., Ozelius, L., Hsu, Y. P., Powell, J., Utterback, M., Gusella, J. F., Bruns, G. A. Gene for A form of human monoamine oxidase (MAOA) maps to Xp21-Xp11. (Abstract) Am. J. Hum. Genet. 41: A209 only, 1987. 2. Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., van Oost, B. A. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262: 578-580, 1993. 3. PDB 2BXS; De Colibus L, Li M, Binda C, Lustig A, Edmondson DE, Mattevi A (September 2005) . Three-dimensional structure of human monoamine oxidase A (MAO A) : relation to the structures of rat MAO A and human MAO B.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

59682 MW

No cross reactivity with other proteins.

6

Amine oxidase [flavin-containing] A

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Belongs to the flavin monoamine oxidase family.

Amine oxidase[flavin-containing] A

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.