Anti-Morg1/WDR83 Antibody Picoband® fluoro488 Vervoeging

MORG1 (mitogen-activated protein kinase organizer 1), a member of the WD-40 protein family that was isolated as a binding partner of the extracellular signal-regulated kinase (ERK) pathway scaffold protein MP1. MORG1 specifically associates with several components of the ERK pathway, including MP1, Raf-1, MEK, and ERK, and stabilizes their assembly into an oligomeric complex. MORG1 facilitates ERK activation when cells are stimulated with lysophosphatidic acid, phorbol 12-myristate 13-acetate, or serum, but not in response to epidermal growth factor. Suppression of MORG1 by short interfering RNA leads to a marked reduction in ERK activity when cells are stimulated with serum. MORG1 is a component of a modular scaffold system that participates in the regulation of agonist-specific ERK signaling.

WD repeat domain-containing protein 83; Mitogen-activated protein kinase organizer 1; MAPK organizer 1; WDR83; MORG1

WDR83

84292

Q9BRX9

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human Morg1, identical to the related mouse and rat sequences.

MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. .

Flow Cytometry

Associated Proteins, Cardiovascular, DNA/RNA, Epigenetics and Nuclear Signaling, Hypoxia, MAPK Pathway, Protein Phosphorylation, RNA Processing, Ser/Thr Kinases, Signal Transduction, Splicing

Immunogen affinity purified.

Liquid

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity) . May also be involved in pre-mRNA splicing. .

1. Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ. Department of Microbiology and Cancer Center, University of Virginia, Charlottesville, VA 22908, USA.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

34343 MW

No cross reactivity with other proteins.

6

WD repeat domain-containing protein 83

Cytoplasm . Nucleus . Predominantly cytoplasmic. Partially nuclear. .

Belongs to the WD repeat MORG1 family.

WD repeat domain-containing protein 83

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.