Anti-MPLKIP Antibody Picoband® 31.0647 Vervoeging

The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy.

MPLKIP; C7orf11; TTDN1; M-phase-specific PLK1-interacting protein; TTD non-photosensitive 1 protein

MPLKIP

136647

Q8TAP9

Human

No cross-reactivity with other proteins

E.coli-derived human MPLKIP recombinant protein (Position: E135-C179) . Human MPLKIP shares 97.7% amino acid (aa) sequence identity with mouse MPLKIP.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Botta, E., Offman, J., Nardo, T., Ricotti, R., Zambruno, G., Sansone, D., Balestri, P., Raams, A., Kleijer, W. J., Jaspers, N. G. J., Sarasin, A., Lehmann, A. R., Stefanini, M. Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships. Hum. Mutat. 28: 92-96, 2007. 2. Jackson, C. E., Weiss, L., Watson, J. H. L. 'Brittle' hair with short stature, intellectual impairment and decreased fertility: an autosomal recessive syndrome in an Amish kindred. Pediatrics 54: 201-212, 1974. 3. Nakabayashi, K., Amann, D., Ren, Y., Saarialho-Kere, U., Avidan, N., Gentles, S., MacDonald, J. R., Puffenberger, E. G., Christiano, A. M., Martinez-Mir, A., Salas-Alanis, J. C., Rizzo, R., Vamos, E., Raams, A., Les, C., Seboun, E., Jaspers, N. G. J., Beckmann, J. S., Jackson, C. E., Scherer, S. W. Identification of C7orf11 (TTDN1) gene mutations and genetic heterogeneity in nonphotosensitive trichothiodystrophy. Am. J. Hum. Genet. 76: 510-516, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

19 kDa

6

M-phase specific PLK1 interacting protein

M-phase-specific PLK1-interacting protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.