Anti-MPP5/PALS1 Antibody Picoband® fluoro594 Vervoeging

This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289) . Multiple transcript variants encoding different isoforms have been found for this gene.

Protein PALS1; Protein associated with Lin-7 1; PALS1; Membrane protein; palmitoylated 5; MAGUK p55 subfamily member 5

PALS1

64398

Q8N3R9

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human MPP5/PALS1 recombinant protein (Position: R86-D386) . Human MPP5/PALS1 shares 95.7% and 96.7% amino acid (aa) sequence identity with mouse and rat MPP5/PALS1, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Kamberov, E., Makarova, O., Roh, M., Liu, A., Karnak, D., Straight, S., Margolis, B. Molecular cloning and characterization of Pals, proteins associated with mLin-7. J. Biol. Chem. 275: 11425-11431, 2000. 2. Roh, M. H., Makarova, O., Liu, C.-J., Shin, K., Lee, S., Laurinec, S., Goyal, M., Wiggins, R., Margolis, B. The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. J. Cell Biol. 157: 161-172, 2002. 3. Tseng, T.-C., Marfatia, S. M., Bryant, P. J., Pack, S., Zhuang, A., O'Brien, J. E., Lin, L., Hanada, T., Chishti, A. H. VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. Biochim. Biophys. Acta 1518: 249-259, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

77kDa

6

Protein associated with LIN7 1, MAGUK p55 family member

Protein PALS1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.