Anti-MPP5/PALS1 Antibody Picoband® HRP Vervoeging

This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289) . Multiple transcript variants encoding different isoforms have been found for this gene.

Protein PALS1; Protein associated with Lin-7 1; PALS1; Membrane protein; palmitoylated 5; MAGUK p55 subfamily member 5

PALS1

64398

Q8N3R9

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human MPP5/PALS1 recombinant protein (Position: R86-D386) . Human MPP5/PALS1 shares 95.7% and 96.7% amino acid (aa) sequence identity with mouse and rat MPP5/PALS1, respectively.

WB, IHC, ELISA

Immunogen affinity purified.

Liquid

1. Kamberov, E., Makarova, O., Roh, M., Liu, A., Karnak, D., Straight, S., Margolis, B. Molecular cloning and characterization of Pals, proteins associated with mLin-7. J. Biol. Chem. 275: 11425-11431, 2000. 2. Roh, M. H., Makarova, O., Liu, C.-J., Shin, K., Lee, S., Laurinec, S., Goyal, M., Wiggins, R., Margolis, B. The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. J. Cell Biol. 157: 161-172, 2002. 3. Tseng, T.-C., Marfatia, S. M., Bryant, P. J., Pack, S., Zhuang, A., O'Brien, J. E., Lin, L., Hanada, T., Chishti, A. H. VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. Biochim. Biophys. Acta 1518: 249-259, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

77kDa

Protein associated with LIN7 1, MAGUK p55 family member

Protein PALS1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.