Anti-MPPB/PMPCB Antibody Picoband® fluoro488 Vervoeging

Mitochondrial-processing peptidase subunit beta is an enzyme that in humans is encoded by the PMPCB gene. This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.

Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166; EVA1A; FAM176A; TMEM166; SP24

PMPCB

9512

O75439

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human MPPB/PMPCB recombinant protein (Position: E23-Q479) .

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Flow Cytometry

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Immunogen affinity purified.

Liquid

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

1. Fields, S., Song, O. A novel genetic system to detect protein-protein interactions. (Letter) Nature 340: 245-246, 1989. 2. Gordon, D. M., Shi, Q., Dancis, A., Pain, D. Maturation of frataxin within mammalian and yeast mitochondria: one-step processing by matrix processing peptidase. Hum. Molec. Genet. 8: 2255-2262, 1999. 3. Gross, M. B. Personal Communication. Baltimore, Md. 5/3/2018.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Eva-1 homolog A, regulator of programmed cell death

Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.