Anti-Mre11 MRE11A Konijn Monoklonale Antilichaam

Boster Bio Anti-Mre11 MRE11A Rabbit Monoclonal Antibody catalog # M00731. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A; MRE11A; HNGS1, MRE11

MRE11A

4361

P49959

Human, Mouse, Rat

A synthesized peptide derived from human Mre11

Clone: AAGG-13

Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level) . Isoform 3 is expressed in lung, pancreas and spleen (at protein level) . Isoform 4 is expressed in lung and pancreas (at protein level) . .

WB, IHC

Apoptosis, Apoptotic Markers, Cancer, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes

Affinity-chromatography

0.5mg/ml

Liquid

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547) . The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416) . In telomeres the MRN complex may modulate t- loop formation (PubMed:10888888) . .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00731

80593 MW

90 kDa

Double-strand break repair protein MRE11A

Nucleus . Chromosome, telomere . Localizes to discrete nuclear foci after treatment with genotoxic agents. .

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.