Anti-MRP3/ABCC3 Antibody Picoband® 31.0647 Vervoeging

Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD64; FCGR1A; FCG1; FCGR1; IGFR1

ABCC3

8714

O15438

Human

No cross-reactivity with other proteins.

E.coli-derived human MRP3/ABCC3 recombinant protein (Position: F214-A275) .

Monocyte/macrophage specific.

Flow Cytometry

Immunoglobulins, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

1. Belinsky, M. G., Bain, L. J., Balsara, B. B., Testa, J. R., Kruh, G. D. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. J. Nat. Cancer Inst. 90: 1735-1741, 1998. 2. Fromm, M. F., Leake, B., Roden, D. M., Wilkinson, G. R., Kim, R. B. Human MRP3 transporter: identification of the 5-prime flanking region, genomic organization and alternative splice variants. Biochim. Biophys. Acta 1415: 369-374, 1999. 3. Kiuchi, Y., Suzuki, H., Hirohashi, T., Tyson, C. A., Sugiyama, Y. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3) . FEBS Lett. 433: 149-152,1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

38779 MW

6

Fc fragment of IgG receptor Ia

Cell membrane.

BAG family molecular chaperone regulator 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.