Anti-MRPS22 Antibody Picoband® fluoro488 Vervoeging

28S ribosomal protein S22, mitochondrial is a protein that in humans is encoded by the MRPS22 gene. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite ion from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq.

Pre T-cell antigen receptor alpha; pT-alpha; pTa; pT-alpha-TCR; PTCRA

MRPS22

56945

P82650

Human

No cross-reactivity with other proteins.

E.coli-derived human MRPS22 recombinant protein (Position: E21-K329) .

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Flow Cytometry

Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage

Immunogen affinity purified.

Liquid

The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. .

1. Chen, A., Tiosano, D., Guran, T., Baris, H. N., Bayram, Y., Mory, A., Shapiro-Kulnane, L., Hodges, C. A., Akdemir, Z. C., Turan, S., Jhangiani, S. N., van den Akker, F., Hoppel, C. L., Salz, H. K., Lupski, J. R., Buchner, D. A. Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum. Molec. Genet. 27: 1913-1926, 2018. 2. Crisponi, L., Deiana, M., Loi, A., Chiappe, F., Uda, M., Amati, P., Bisceglia, L., Zelante, L., Nagaraja, R., Porcu, S., Ristaldi, M. S., Marzella, R., and 10 others. The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nature Genet. 27: 159-166, 2001. 3. Crisponi, L., Uda, M., Deiana, M., Loi, A., Nagaraja, R., Chiappe, F., Schlessinger, D., Cao, A., Pilia, G. FOXL2 inactivation by a translocation 171 kb away: analysis of 500 kb of chromosome 3 for candidate long-range regulatory sequences. Genomics 83: 757-764, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

41409 MW

6

Pre T cell antigen receptor alpha

Membrane; Single-pass type I membrane protein.

Protein NDRG3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.