Anti-MSLNL Antibody Picoband® 31.0550 Vervoeging

Loss of gene function is implicated in the emergence of novel phenotypes during organism evolution. Human MSLNL has a nonsense mutation in exon 10 and two polymorphic mutations: a frameshift in exon 3 and a nonsense codon in exon 8. The gorilla gene also shows multiple deleterious mutations, including a premature stop codon, a deletion, and a splice site mutation. Molecular evolutionary analysis indicated relaxed selection pressure on MSLNL in African great ape lineages, which suggested that MSLNL might have become inactivated before the divergence of human, chimpanzee and gorilla. The mouse Mslnl gene is highly expressed in olfactory epithelium and moderately expressed in several other tissues. We propose that the loss of MSLNL may be associated with the evolution of the olfactory system in African great apes including human.

Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; PYROXD1

MSLNL

401827

Q96KJ4

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human MSLNL recombinant protein (Position: Q65-H423) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Involved in cellular response to oxidative stress.

1. B, D. W. K. A. , C, S. J. , A, D. S. K. , D, H. S. K. , A, S. B. S. , & A, Y. H. . (2012) . Inactivation of the mslnl gene encoding mesothelin-like protein during african great ape evolution. Gene, 496 (1), 17-21. 2. Hollevoet, K. , Nackaerts, K. , Gosselin, R. , Wever, W. D. , & Meerbeeck, J. P. V. . (2011) . Soluble mesothelin, megakaryocyte potentiating factor, and osteopontin as markers of patient response and outcome in mesothelioma. Journal of Thoracic Oncology, 6 (11), 1930-1937. 3. Daniels, R. J. , Peden, J. F. , Lloyd, C. , Horsley, S. W. , & Higgs, D. R. . (2001) . Sequence, structure and pathology of the fully annotated terminal 2 mb of the short arm of human chromosome 16. Human Molecular Genetics, 10 (4), 339-352.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Pyridine nucleotide-disulphide oxidoreductase domain 1

Nucleus. Sarcomere.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.