Anti-MST3/STK24 Antibody Picoband® 31.0647 Vervoeging

Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the STK24 gene located in the chromosome 13, band q32.2.

Olfactomedin-4; OLM4; Antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein; hGC-1; hOLfD; OLFM4; GW112; UNQ362; PRO698

STK24

8428

Q9Y6E0

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human MST3/STK24 recombinant protein (Position: M1-Y433) .

Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level) . Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.

1. Irwin, N., Li, Y.-M., O'Toole, J. E., Benowitz, L. I. Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth. Proc. Nat. Acad. Sci. 103: 18320-18325, 2006. 2. Lee, W.-S., Hsu, C.-Y., Wang, P.-L., Huang, C.-Y. F., Chang, C.-H., Yuan, C.-J. Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3. FEBS Lett. 572: 41-45, 2004. 3. Schinkmann, K., Blenis, J. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. J. Biol. Chem. 272: 28695-28703, 1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

211344 MW

6

Olfactomedin 4

Extracellular space. Mitochondrion.

Chromodomain-helicase-DNA-binding protein 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.