Anti-MST4/STK26 Antibody Picoband® 31.0647 Vervoeging

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Mediator of RNA polymerase II transcription subunit 20; Mediator complex subunit 20; TRF-proximal protein homolog; hTRFP; MED20; TRFP

STK26

51765

Q9P289

Human, Rat

No cross-reactivity with other proteins.

E.coli-derived human MST4/STK26 recombinant protein (Position: K233-P416) .

Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Flow Cytometry

Epigenetics and Nuclear Signaling, Mediator Complex, Transcription

Immunogen affinity purified.

Liquid

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. An, L., Nie, P., Chen, M., Tang, Y., Zhang, H., Guan, J., Cao, Z., Hou, C., Wang, W., Zhao, Y., Xu, H., Jiao, S., Zhou, Z. MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway. J. Exp. Med. 217: e20191817, 2020. Note: Electronic Article. 2. Dan, I., Ong, S.-E., Watanabe, N. M., Blagoev, B., Nielsen, M. M., Kajikawa, E., Kristiansen, T. Z., Mann, M., Pandey, A. Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. J. Biol. Chem. 277: 5929-5939, 2002. 3. Qian, Z., Lin, C., Espinosa, R., LeBeau, M., Rosner, M. R. Cloning and characterization of MST4, a novel Ste20-like kinase. J. Biol. Chem. 276: 22439-22445, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

CD72 molecule

Nucleus .

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.