Anti-MTAP Antibody Picoband® 0,00647 Vervoeging

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene.

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit IV isoform 1; COX IV-1; COX4I1; COX4

MTAP

4507

Q13126

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human MTAP recombinant protein (Position: E31-H283) .

Ubiquitous.

Flow Cytometry

Cancer, Cancer Metabolism, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolism, Mitochondria, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Organelles, Oxidative Phosphorylation, Pathways and Processes, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Immunogen affinity purified.

Liquid

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

1. Arnold, W. H. Hereditary bone dysplasia with sarcomatous degeneration. Ann. Intern. Med. 78: 902-906, 1973. 2. Burdon, K. P., Macgregor, S., Hewitt, A. W., Sharma, S., Chidlow, G., Mills, R. A., Danoy, P., Casson, R., Viswanathan, A. C., Liu, J. Z., Landers, J., Henders, A. K., and 13 others. Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. Nature Genet. 43: 574-578, 2011. 3. Camacho-Vanegas, O., Camacho, S. C., Till, J., Miranda-Lorenzo, I., Terzo, E., Ramirez, M. C., Schramm, V., Cordovano, G., Watts, G., Mehta, S., Kimonis, V., Hoch, B., Philibert, K. D., Raabe, C. A., Bishop, D. F., Glucksman, M. J., Martignetti, J. A. Primate genome gain and loss: a bone dysplasia, muscular dystrophy, and bone cancer syndrome resulting from mutated retroviral-derived MTAP transcripts. Am. J. Hum. Genet. 90: 614-627, 2012.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39411 MW

6

Cytochrome c oxidase subunit 4I1

Mitochondrion inner membrane.

Zinc finger protein Helios

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.