Anti-MTCH2 Antibody Picoband® 0,00647 Vervoeging

Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene. This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons.

MTCH2

23788

Q9Y6C9

Human, Rat

E.coli-derived human MTCH2 recombinant protein (Position: M1-I303) . Human MTCH2 shares 93.7% amino acid (aa) sequence identity with mouse MTCH2.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Willer, C. J., Speliotes, E. K., Loos, R. J. F., Li, S., Lindgren, C. M., Heid, I. M., Berndt, S. I., Elliott, A. L., Jackson, A. U., Lamina, C., Lettre, G., Lim, N., and 134 others. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genet. 41: 25-34, 2009. 2. Yerushalmi, G. M., Leibowitz-Amit, R., Shaharabany, M., Tsarfaty, I. Met-HGF/SF signal transduction induces Mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization. Neoplasia 4: 510-522, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

33 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.