Anti-MUC2 Antilichaam 31.0550 Vervoeging

Mucin 2, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. This gene encodes a member of the mucin protein family. It is mapped to 11p15.5. Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium. The primary function of the MUC2 gene product is to provide a protective barrier between the epithelial surfaces and the gut lumen. There is decreased expression of MUC2 in colonic cancer and defective polymerization of secreted mucin in ulcerative colitis.

Mucin-2; MUC-2; Intestinal mucin-2; MUC2; SMUC

MUC2

4583

Q02817

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human MUC2 recombinant protein (Position: S21-C255) .

Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.

Flow Cytometry

Cancer, Cell Type Markers, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Tags & Cell Markers, Tumor Associated, Tumor Immunology, Tumor-Associated Antigens

Immunogen affinity purified.

Liquid

Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

1. Allen, A., Hutton, D. A., Pearson, J. P. The MUC2 gene product: a human intestinal mucin. Int. J. Biochem. Cell Biol. 30: 797-801, 1998. 2. Rousseau K, Byrne C, Kim YS, Gum JR, Swallow DM, Toribara NW (May 2004) . The complete genomic organization of the human MUC6 and MUC2 mucin genes. Genomics 83 (5) : 936–9.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

123799 MW

6

Mucin 2, oligomeric mucus/gel-forming

Secreted. In the intestine, secreted into the inner and outer mucus layers.

Vinculin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.