Anti-MUC5B Antilichaam 31.0550 Vervoeging

Mucin 5B (MUC5B/Muc5b) is a protein that in humans is encoded by the MUC5B gene and by Muc5b gene in mouse. This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.

Folliculin; BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; FLCN; BHD

MUC5B

727897

Q9HC84

Human

No cross-reactivity with other proteins.

E.coli-derived human MUC5B recombinant protein (Position: A5688-V5762) .

Skeletal muscle, heart, colon, testis, ovary and pancreas.

Flow Cytometry

Biochemicals, Chemical Type, Neuroscience, Neurotransmission, Obesity, Receptors / Channels

Immunogen affinity purified.

Liquid

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

1. Desseyn, J.-L., Aubert, J.-P., van Seuningen, I., Porchet, N., Laine, A. Genomic organization of the 3-prime region of the human mucin gene MUC5B. J. Biol. Chem. 272: 16873-16883, 1997. 2. Desseyn, J.-L., Buisine, M. P., Porchet, N., Aubert, J.-P., Laine, A. Genomic organization of the human mucin gene MUC5B, cDNA and genomic sequences upstream of the large central exon. J. Biol. Chem. 273: 30157-30164, 1998. 3. Desseyn, J.-L., Guyonnet-Duperat, V., Porchet, N., Aubert, J.-P., Laine, A. Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat: structural evidence for a 11p15.5 gene family. J. Biol. Chem. 272: 3168-3178, 1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

28994 MW

6

Folliculin

Cytoplasm. Nucleus.

Emerin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.