Anti-MUS81 Antibody Picoband® 31.0550 Vervoeging

Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

Lipopolysaccharide-binding protein; LBP; Lbp

MUS81

80198

Q96NY9

Human, Rat

No cross-reactivity with other proteins.

E.coli-derived human MUS81 recombinant protein (Position: R6-C545) .

Detected in blood serum (at protein level) .

Flow Cytometry

Defensin, Human Protein, Immunology, Innate Immunity, Macrophage/Inflammation, Microbiology, Protein, TLR Signaling

Immunogen affinity purified.

Liquid

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:9144073) . Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity) . Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24380872) .

1. Chen, X.-B., Melchionna, R., Denis, C.-M., Gaillard, P.-H. L., Blasina, A., Van de Weyer, I., Boddy, M. N., Russell, P., Vialard, J., McGowan, C. H. Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Molec. Cell 8: 1117-1127, 2001. 2. Ciccia, A., Constantinou, A., West, S. C. Identification and characterization of the human Mus81-Eme1 endonuclease. J. Biol. Chem. 278: 25172-25178, 2003. 3. Ciccia, A., Ling, C., Coulthard, R., Yan, Z., Xue, Y., Meetei, A. R., Laghmani, E. H., Joenje, H., McDonald, N., de Winter, J. P., Wang, W., West, S. C. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Molec. Cell 25: 331-343, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

53384 MW

6

Lipopolysaccharide binding protein

Secreted

Lipopolysaccharide-binding protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.