Anti-Muscarinic Acetylcholine Receptor 2/CHRM2 Antibody Picoband® fluoro488 Vervoeging

The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.

Muscarinic acetylcholine receptor M2; CHRM2

CHRM2

1129

P08172

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Muscarinic Acetylcholine Receptor 2, identical to the related rat and mouse sequences.

Flow Cytometry

Adapters, Cell Biology, Cell Type Markers, Signal Transduction, Tags & Cell Markers, Transmembrane

Immunogen affinity purified.

Liquid

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3) ; this then triggers calcium ion release into the cytosol. .

1. Entrez Gene: CHRM2 cholinergic receptor, muscarinic 2. 2. Comings DE, Wu S, Rostamkhani M, McGue M, Lacono WG, Cheng LS, MacMurray JP (January 2003) . Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition. Mol. Psychiatry. 8 (1) : 10–1. 3. Gosso MF, van Belzen M, de Geus EJ, Polderman JC, Heutink P, Boomsma DI, Posthuma D (November 2006) . Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families. Genes Brain Behav. 5 (8) : 577–84.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

51715 MW

No cross reactivity with other proteins.

6

Muscarinic acetylcholine receptor M2

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Phosphorylation in response to agonist binding promotes receptor internalization. .

Muscarinic acetylcholine receptor M2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.