Anti-MYH14 Antibody Picoband® fluoro488 Vervoeging

Myosin-14 is a protein that in humans is encoded by the MYH14 gene. This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14) . Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.

MYH14

79784

Q7Z406

Human, Mouse, Rat

E.coli-derived human MYH14 recombinant protein (Position: M1-R1895) . Human MYH14 shares 92.5% amino acid (aa) sequence identity with mouse MYH14.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Choi, B.-O., Kang, S. H., Hyun, Y. S., Kanwal, S., Park, S. W., Koo, H., Kim, S.-B., Choi, Y.-C., Yoo, J. H., Kim, J.-W., Park, K. D., Choi, K.-G., Kim, S. J., Zuchner, S., Chung, K. W. A complex phenotype of peripheral neuropathy, myopathy, hoarseness, and hearing loss is linked to an autosomal dominant mutation in MYH14. Hum. Mutat. 32: 669-677, 2011. 2. Donaudy, F., Snoeckx, R., Pfister, M., Zenner, H.-P., Blin, N., Di Stazio, M., Ferrara, A., Lanzara, C., Ficarella, R., Declau, F., Pusch, C. M., Nurnberg, P., Melchionda, S., Zelante, L., Ballana, E., Estivill, X., Van Camp, G., Gasparini, P., Savoia, A. Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4) . Am. J. Hum. Genet. 74: 770-776, 2004. 3. Golomb, E., Ma, X., Jana, S. S., Preston, Y. A., Kawamoto, S., Shoham, N. G., Goldin, E., Conti, M. A., Sellers, J. R., Adelstein, R. S. Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family. J. Biol. Chem. 279: 2800-2808, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.