Anti-MYL4 Antibody Picoband® fluoro488 Vervoeging

Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene. Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

MYL4; MLC1; PRO1957; Myosin light chain 4; Myosin light chain 1, embryonic muscle/atrial isoform; Myosin light chain alkali GT-1 isoform

MYL4

4635

P12829

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequencein the middle region of human MYL4.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Cohen-Haguenauer, O., Barton, P. J. R., Van Cong, N., Cohen, A., Masset, M., Buckingham, M., Frezal, J. Chromosomal assignment of two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform (MYL3, MYL4) . Hum. Genet. 81: 278-282, 1989. 2. Orr, N., Arnaout, R., Gula, L. J., Spears, D. A., Leong-Sit, P., Li, Q., Tarhuni, W., Reischauer, S., Chauhan, V. S., Borkovich, M., Uppal, S., Adler, A., Coughlin, S. R., Stainier, D. Y. R., Gollob, M. H. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nature Commun 7: 11303, 2016. Note: Electronic Article. 3. Seharaseyon, J., Bober, E., Hsieh, C.-L., Fodor, W. L., Francke, U., Arnold, H.-H., Vanin, E. F. Human embryonic/atrial myosin alkali light chain gene: characterization, sequence and chromosomal location. Genomics 7: 289-293, 1990.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

22 kDa

6

Myosin light chain 4

Myosin light chain 4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.