Anti-n-Myc (Neuroblastoma Marker) Monoklonale Antilichaam (Kloon: NMYC-1)

The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throμghout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.

Class E basic helix-loop-helix protein 37 (bHLHe37) ; MODED; N-myc proto-oncogene protein; Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene; ODED; pp65/67; v myc (avian) myelocytomatosis viral related oncogene neuroblastoma derived

MYCN

4613

P04198

Human, Mouse, Rat

Recombinant full-length human n-Myc protein.

NMYC-1

IF, WB

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Immunofluorescence (1-2ug/ml) ; Western Blot (1-2ug/ml)

Mouse IgG2a, kappa