Anti-NALP7 NLRP7 Antilichaam

NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1β secretion and is a feedback regulator of interleukin-1β secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.

Boster Bio Anti-NALP7 NLRP7 Antibody (Catalog # A07838) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

HYDM, PAN7, NALP7, NOD12, PYPAF3, CLR19.4, NACHT, LRR and PYD domains-containing protein 7, Nucleotide-binding oligomerization domain protein 12

NLRP7

Q8WX94

Human

NALP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7. The immunogen is located within amino acids 90 - 140 of NALP7.

Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.

ELISA, WB, IHC-P, IF

Innate Immunity

NALP7 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Inhibits CASP1/caspase-1-dependent IL1B secretion.

Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A07838

111807 MW

NLR family, pyrin domain containing 7

NLR family, pyrin domain containing 7

IgG

NALP7 Antibody is supplied in PBS containing 0.02% sodium azide.