Anti-Nanos homolog 2 Nanos2 Antilichaam

Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.

Boster Bio Anti-Nanos homolog 2 Nanos2 Antibody (Catalog # A07978) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

NOS2, NOS2, Nanos homolog 2, NOS-2

NANOS2

P60321

Human, Mouse, Rat

This Nanos2 antibody will not cross-react with either Nanos 1 or Nanos3.

Nanos2 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Nanos2. The immunogen is located within the last 50 amino acids of Nanos2.

Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level) .

ELISA, WB

Signal Transduction

Nanos2 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity) . .

Nanos2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A07978

15132 MW

Nanos homolog 2 (Drosophila)

Cytoplasm

Nanos homolog 2 (Drosophila)

IgG

Nanos2 Antibody is supplied in PBS containing 0.02% sodium azide.