Anti-NANS Antibody Picoband®

Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene. This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.

Boster Bio Anti-NANS Antibody Picoband® catalog # A08540-2. Tested in WB, ICC/IF, ELISA applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

NANS; SAS; Sialic acid synthase; N-acetylneuraminate synthase; EC 2.5.1.56; N-acetylneuraminate-9-phosphate synthase; EC 2.5.1.57; N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthase

NANS

54187

Q9NR45

Human, Rat

No cross-reactivity with other proteins

E.coli-derived human NANS recombinant protein (Position: M1-E341) . Human NANS shares 96.2% amino acid (aa) sequence identity with mouse NANS.

WB, ICC/IF, ELISA

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

1. Camera, G., Camera, A., Gatti, R. Sponastrime dysplasia: report on two siblings with mental retardation. Pediat. Radiol. 23: 611-614, 1993. 2. Genevieve, D., Heron, D., El Ghouzzi, V., Prost-Squarcioni, C., Le Merrer, M., Jacquette, A., Sanlaville, D., Pinton, F., Villeneuve, N., Kalifa, G., Munnich, A., Cormier-Daire, V. Exclusion of the dymeclin and PAPSS2 genes in a novel form of spondyloepimetaphyseal dysplasia and mental retardation. Europ. J. Hum. Genet. 13: 541-546, 2005. 3. Lawrence, S. M., Huddleston, K. A., Pitts, L. R., Nguyen, N., Lee, Y. C., Vann, W. F., Coleman, T. A., Betenbaugh, M. J. Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability. J. Biol. Chem. 275: 17869-17877, 2000.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A08540-2

40 kDa

38 kDa

N-acetylneuraminate synthase

Sialic acid synthase

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.