Anti-NAT6/FUS2/NAA80 Antibody Picoband® HRP Vervoeging

This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon.

NAA80; FUS2; NAT6; N-alpha-acetyltransferase 80; HsNAAA80; EC 2.3.1.-; N-acetyltransferase 6; Protein fusion-2; Protein fus-2

NAA80

24142

Q93015

Human, Mouse

No cross-reactivity with other proteins

E.coli-derived human NAT6/FUS2/NAA80 recombinant protein (Position: M1-I286) . Human NAT6/FUS2/NAA80 shares 69.4% amino acid (aa) sequence identity with mouse NAT6/FUS2/NAA80.

WB, IHC, ELISA

Immunogen affinity purified.

Liquid

1. Drazic, A., Aksnes, H., Marie, M., Boczkowska, M., Varland, S., Timmerman, E., Foyn, H., Glomnes, N., Rebowski, G., Impens, F., Gevaert, K., Dominguez, R., Arnesen, T. NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. Proc. Nat. Acad. Sci. 115: 4399-4404, 2018. 2. Goris, M., Magin, R. S., Foyn, H., Myklebust, L. M., Varland, S., Ree, R., Drazic, A., Bhambra, P., Stove, S. I., Baumann, M., Haug, B. E., Marmorstein, R., Arnesen, T. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proc. Nat. Acad. Sci. 115: 4405-4410, 2018. 3. Lerman, M. I., Minna, J. D. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. Cancer Res. 60: 6116-6133, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

31 kDa

N-alpha-acetyltransferase 80, NatH catalytic subunit

N-alpha-acetyltransferase 80

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.