Anti-NCOA5 Antibody Picoband® fluoro550 Vervoeging

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene. This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene.

Protein SOX-15; Protein SOX-12; Protein SOX-20; SOX15; SOX12; SOX20; SOX26; SOX27

NCOA5

57727

Q9HCD5

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human NCOA5 recombinant protein (Position: R191-Q560) .

Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.

Flow Cytometry

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Immunogen affinity purified.

Liquid

Binds to the 5'-AACAAT-3' sequence.

1. Gao, S., Li, A., Liu, F., Chen, F., Williams, M., zhang, C., Kelley, Z., Wu, C.-L., Luo, R., Xiao, H. NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell 24: 725-737, 2013. 2. Sauve, F., McBroom, L. D. B., Gallant, J., Moraitis, A. N., Labrie, F., Giguere, V. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. Molec. Cell. Biol. 21: 343-353, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49229 MW

6

SRY-box 15

Nucleus.

Chromaffin granule amine transporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.