Anti-NCR1 Antilichaam 31.0647 Vervoeging

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene. Predicted to be involved in cellular defense response; regulation of natural killer cell mediated cytotoxicity; and signal transduction. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be part of SWI/SNF complex. Predicted to be active in plasma membrane. Biomarker of acquired immunodeficiency syndrome; anogenital venereal wart; hepatitis C; and lymphoproliferative syndrome.

Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335; NCR1; LY94

NCR1

9437

O76036

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human NCR1 recombinant protein (Position: A55-R258) .

Selectively expressed by both resting and activated NK cells.

Flow Cytometry

Adapters, Adaptive Immunity, Immunology, Signal Transduction, T Cells, Transmembrane

Immunogen affinity purified.

Liquid

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

1. Gazit, R., Gruda, R., Elboim, M., Arnon, T. I., Katz, G., Achdout, H., Hanna, J., Qimron, U., Landau, G., Greenbaum, E., Zakay-Rones, Z., Porgador, A., Mandelboim, O. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nature Immun. 7: 517-523, 2006. 2. Narni-Mancinelli, E., Jaeger, B. N., Bernat, C., Fenis, A., Kung, S., De Gassart, A., Mahmood, S., Gut, M., Heath, S. C., Estelle, J., Bertosio, E., Vely, F., Gastinel, L. N., Beutler, B., Malissen, B., Malissen, M., Gut, I. G., Vivier, E., Ugolini, S. Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science 335: 344-348, 2012. 3. Pessino, A., Sivori, S., Bottino, C., Malaspina, A., Morelli, L., Moretta, L., Biassoni, R., Moretta, A. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J. Exp. Med. 188: 953-960, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Natural cytotoxicity triggering receptor 1

Cell membrane; Single-pass type I membrane protein.

Platelet endothelial cell adhesion molecule

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.