Anti-NDFIP1 Antibody Picoband® fluoro488 Vervoeging

Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene. The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins.

Solute carrier family 12 member 5; Electroneutral potassium-chloride cotransporter 2; K-Cl cotransporter 2; hKCC2; Neuronal K-Cl cotransporter; SLC12A5; KCC2; KIAA1176

NDFIP1

80762

Q9BT67

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human NDFIP1 recombinant protein (Position: A10-Y221) .

Brain specific. Detected in neuronal cells.

Flow Cytometry

Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels

Immunogen affinity purified.

Liquid

Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl- homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl- levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.

1. Foot, N. J., Leong, Y. A., Dorstyn, L. E., Dalton, H. E., Ho, K., Zhao, L., Garrick, M. D., Yang, B., Hiwase, D., Kumar, S. Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis. Blood 117: 638-646, 2011. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 6/11/2008. 3. Harvey, K. F., Shearwin-Whyatt, L. M., Fotia, A., Parton, R. G., Kumar, S. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J. Biol. Chem. 277: 9307-9317, 2002

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Solute carrier family 12 member 5

Membrane. Multi-pass membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.