Anti-NDRG4 Antibody Picoband® 31.0550 Vervoeging

Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.

Transmembrane protein 107; TMEM107; DC20, UNQ638/PRO1268

NDRG4

65009

Q9ULP0

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human NDRG4 recombinant protein (Position: M1-R226) .

Ubiquitous. .

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity) . .

1. Hirosawa, M., Nagase, T., Ishikawa, K., Kikuno, R., Nomura, N., Ohara, O. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. DNA Res. 6: 329-336, 1999. 2. Hongo, S., Watanabe, T., Takahashi, K., Miyazaki, A. Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. J. Cell. Biochem. 98: 185-193, 2006. 3. Linhares, N. D., Freire, M. C. M., Cardenas, R. G. C. C. L., Pena, H. B., Bahia, M., Pena, S. D. J. Exome sequencing identifies a novel homozygous variant in NDRG4 in a family with infantile myofibromatosis. Europ. J. Med. Genet. 57: 643-648, 2014.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

15503 MW

6

Transmembrane protein 107

Membrane ; Multi-pass membrane protein .

Transmembrane protein 107

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.