Anti-NECAB2 Antibody Picoband® fluoro550 Vervoeging

N-terminal EF-hand calcium-binding protein 2 is a protein that in humans is encoded by the NECAB2 gene. The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A (2A) receptor and metabotropic glutamate receptor type 5.

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

NECAB2

54550

Q7Z6G3

Human

No cross-reactivity with other proteins

E.coli-derived human NECAB2 recombinant protein (Position: M1-E337) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. Bernier, G., Vukovich, W., Neidhardt, L., Herrmann, B. G., Gruss, P. Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium. Development 128: 3987-3994, 2001. 2. Canela, L., Lujan, R., Lluis, C., Burgueno, J., Mallol, J., Canela, E. I., Franco, R., Ciruela, F. The neuronal Ca (2+) -binding protein 2 (NECAB2) interacts with the adenosine A (2A) receptor and modulates the cell surface expression and function of the receptor. Molec. Cell Neurosci. 36: 1-12, 2007. 3. Zhang, M.-D., Barde, S., Szordorai, E., Josephson, A., Mitsios, N., Watanabe, M., Attems, J., Lubec, G., Kovacs, G. G., Uhlen, M., Mulder, J., Harkany, T., Hokfelt, T. Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord. Brain Struct. Funct. 221: 3803-3823, 2016. Note: Erratum: Brain Struct. Funct. 221: 3843, 2016.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

RNA-binding protein 47

Nucleus .

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.