Anti-Nesprin3/SYNE3 Antibody Picoband® fluoro647 Vervoeging

Enables actin filament binding activity and cytoskeleton-nuclear membrane anchor activity. Involved in cytoskeleton organization; establishment of protein localization to membrane; and regulation of cell shape. Located in nuclear membrane. Part of meiotic nuclear membrane microtubule tethering complex. Biomarker of Huntington's disease.

Follicular dendritic cell secreted peptide; FDC secreted protein; FDC-SP; FDCSP; C4orf7; UNQ733/PRO1419

SYNE3

161176

Q6ZMZ3

Human, Mouse

No cross-reactivity with other proteins

E.coli-derived human Nesprin3/SYNE3 recombinant protein (Position: R322-L495) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Immunology, Secreted Molecules

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. Gob, E., Schmitt, J., Benavente, R., Alsheimer, M. Mammalian sperm head formation involves different polarization of two novel LINC complexes. PLoS One 5: e12072, 2010. Note: Electronic Article. 2. Wilhelmsen, K., Litjens, S. H. M., Kuikman, I., Tshimbalanga, N., Janssen, H., van den Bout, I., Raymond, K., Sonnenberg, A. Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin. J. Cell Biol. 171: 799-810, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

9700 MW

6

Follicular dendritic cell secreted peptide

Secreted.

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.