Anti-NEURL4 Antibody Picoband® 31.0550 Vervoeging

The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants.

Negative elongation factor B; NELF-B; Cofactor of BRCA1; NELFB; COBRA1; KIAA1182

NEURL4

84461

Q96JN8

Human

No cross-reactivity with other proteins.

E.coli-derived human NEURL4 recombinant protein (Position: E519-E1562) .

Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.

Flow Cytometry

Epigenetics and Nuclear Signaling, Transcription

Immunogen affinity purified.

Liquid

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. May be able to induce chromatin unfolding.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 6/26/2014. 2. Li, J., Kim, S., Kobayashi, T., Liang, F.-X., Korzeniewski, N., Duensing, S., Dynlacht, B. D. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. EMBO Rep. 13: 547-553, 2012. 3. Nagase, T., Nakayama, M., Nakajima, D., Kikuno, R., Ohara, O. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Negative elongation factor complex member B

Nucleus.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.