Anti-Neuropilin-1 (a1 CUB-domein) Antilichaam

Neuropilins are transmembrane proteins that contain two CUB domains (a1 and a2), two coagulation factor-like domains (b1 and b2), and a MAM domain in the extracellular region. These proteins have short cytoplasmic domains that include a PDZ-binding motif. The neuropilin (NRP) family includes NRP-1, NRP-2A, and NRP-2B. NRP-1 has been implicated as a receptor involved in axon guidance and VEGF signaling. NRP-1 mediates activation of intracellular signaling pathways through interaction with its co-receptors, Plexin-A1 and VEGFRs. The expression of NRP-1, along with the co-receptor Plexin-A1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A-containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury.

Our Neuropilin-1 (a1 CUB Domain) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat Neuropilin-1 (a1 CUB Domain) and is protein g purified. It is great for use in ELISA, WB, ICC, IHC.

Our Neuropilin-1 (a1 CUB Domain) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat Neuropilin-1 (a1 CUB Domain) and is Protein G purified. It is great for use in WB, ICC, IHC.

NRP1, VEGF 165, VEGFR

NRP1

O14786

Human, Mouse, and Rat

Clone M534 was generated from a neuropilin-1 synthetic peptide (coupled to carrier protein) corresponding to amino acids within the a1 CUB domain of human neuropilin-1. This sequence is highly conserved in rat and mouse neuropilin-1, and has low homology to neuropilin-2.

Neuropilin-1 (a1 CUB Domain)

M534

Unconjugated

ELISA, WB, ICC, IHC

Cell Signaling, Growth Factor Signaling

Protein G Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

130

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Protein G purified culture supernatant.

1:100

1:250

The antibody detects a 130 kDa* protein corresponding to the apparent molecular mass of neuropilin-1 on SDS-PAGE immunoblots of human recombinant neuropilin-1 and in human PC3 cells.

1:100

Western blots performed on each lot.

Mouse

Liquid

IgG1

Human

Quality Control: WB

AB_3068478