Anti-NFIP2 NDFIP2 Antilichaam

Boster Bio Anti-NFIP2 NDFIP2 Antibody catalog # A08384. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.

NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A; Putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF-kappa-B-activating protein 413; NDFIP2; KIAA1165, N4WBP5A

NDFIP2

Q9NV92

Human, Mouse

Synthesized peptide derived from part region of human protein

Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta.

WB, ELISA

NFIP2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/mL

Liquid

Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003) . May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity) .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A08384

36390 MW

NEDD4 family-interacting protein 2

Endosome membrane

NEDD4 family-interacting protein 2

IgG

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.