Anti-NFKBIZ Antibody Picoband® fluoro550 Vervoeging

NF-kappa-B inhibitor zeta (IκBζ) is a protein that in humans is encoded by the NFKBIZ gene.This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS) . The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.

Loricrin; LOR; LRN

NFKBIZ

64332

Q9BYH8

Human

No cross-reactivity with other proteins.

E.coli-derived human NFKBIZ recombinant protein (Position: Q247-H577) .

Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.

Flow Cytometry

Cell Biology, Cytokines, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Interferons, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin & Ubiquitin Like Modifiers, Ubiquitin E3 Enzymes

Immunogen affinity purified.

Liquid

Major keratinocyte cell envelope protein.

1. Bambouskova, M., Gorvel, L., Lampropoulou, V., Sergushichev, A., Loginicheva, E., Johnson, K., Korenfeld, D., Mathyer, M. E., Kim, H., Huang, L.-H., Duncan, D., Bregman, H., and 19 others. Electrophilic properties of itaconate and derivatives regulate the I-kappa-B-zeta-ATF3 inflammatory axis. Nature 556: 501-504, 2018. 2. Eto, A., Muta, T., Yamazaki, S., Takeshige, K. Essential roles for NF-kappa-B and a Toll/IL-1 receptor domain-specific signal (s) in the induction of I-kappa-B-zeta. Biochem. Biophys. Res. Commun. 301: 495-501, 2003. 3. Gross, M. B. Personal Communication. Baltimore, Md. 5/19/2020.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39411 MW

6

Loricrin

Nucleoplasm. Cytoplasm.

Zinc finger protein Helios

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.