Anti-NFRKB Antibody Picoband® fluoro550 Vervoeging

NFRKB (nuclear factor related to kappa-B-binding protein) was first identified as a factor that could bind a variant NF-kappa B site in the interleukin-2 receptor alpha (IL-2R alpha) gene. NFRKB appears to be a transcription factor central to immune cell development. Evidence of this comes from the identification of NFRKB as an amplified gene in several cases of acute myeloid leukemia. Additionally, in another clinical case, a partial deletion of the chromosomal region that includes NFRKB is shown to be associated with combined cellular immunodeficiency.

Angiomotin-like protein 2; Leman coiled-coil protein; LCCP; AMOTL2; KIAA0989

NFRKB

4798

Q6P4R8

Human

No cross-reactivity with other proteins.

E.coli-derived human NFRKB recombinant protein (Position: H270-L994) .

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

1. Adams, B. S., Leung, K., Meltzer, P. S., Lewis, K. A., Wagner-McPherson, C., Evans, G. A., Nabel, G. J. Localization of the gene encoding R-kappa-B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25. Genomics 14: 270-274, 1992.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Angiomotin like 2

Recycling endosome.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.