Anti-NHLRC2 Antibody Picoband® fluoro550 Vervoeging

NHL Repeat Containing Protein 2, or NHLRC2, is a protein encoded by the NHLRC2 gene. NHLRC2 (NHL repeat containing 2) is a 726 amino acid protein that contains six NHL repeats and one thioredoxin domain. Existing as two alternatively spliced isoforms, NHLRC2 is encoded by a gene that maps to human chromosome 10q25.3. Spanning nearly 135 million base pairs, chromosome 10 makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; PYROXD1

NHLRC2

374354

Q8NBF2

Human

No cross-reactivity with other proteins.

E.coli-derived human NHLRC2 recombinant protein (Position: E67-Q588) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Involved in cellular response to oxidative stress.

1. Biterova, E., Ignatyev, A., Uusimaa, J., Hinttala, R., Ruddock, L. W. Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease. PLoS One 13: e0202391, 2018. Note: Electronic Article. 2. Brodsky, N. N., Boyarchuk, O., Kovalchuk, T., Hariyan, T., Rice, A., Ji, W., Khokha, , M., Lakhani, S., Lucas, C. L. Novel compound heterozygous variants in NHLRC2 in a patient with FINCA syndrome. J. Hum. Genet. 65: 911-915, 2020. 3. Gross, M. B. Personal Communication. Baltimore, Md. 1/17/2019.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Pyridine nucleotide-disulphide oxidoreductase domain 1

Nucleus. Sarcomere.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.