Anti-Nicastrin/NCSTN Antibody Picoband® fluoro594

Nicastrin, also known as?NCSTN, is a?protein?that is a part of the gamma secretase?protein complex. It is mapped to 1q23.2. This gene is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the gamma secretase?protein complex, all of which undergo significant post-translational modification?before becoming active in the cell. NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex.?The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly.?The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease. Nicastrin has also been identified as a regulator of neprilysin, an?enzyme?involved in the degradation of amyloid beta fragment.

Nicastrin; NCSTN; KIAA0253; UNQ1874/PRO4317

NCSTN

23385

Q92542

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human Nicastrin, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Widely expressed. .

Flow Cytometry

Alzheimer's Disease, Cytoplasmic, Neurodegenerative Disease, Neurology Process, Neuroscience, Signaling Pathways, Stem Cells

Immunogen affinity purified.

Liquid

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein) . It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

1. Entrez Gene: NCSTN nicastrin 2. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996) .Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 3 (5) : 321–9, 341–54. 3. Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H (April 2005) .Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.J. Biol. Chem. 280 (17) : 17020–6.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

78411 MW

No cross reactivity with other proteins.

6

Nicastrin

Membrane ; Single-pass type I membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.

Nicastrin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.