Anti-Ninein/NIN Antibody Picoband® fluoro647 Vervoeging

Ninein is a protein that in humans is encoded by the NIN gene. This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.

Endoglin; Cell surface MJ7/18 antigen; CD105; Eng; Edg

NIN

51199

Q8N4C6

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Ninein/NIN recombinant protein (Position: Q1023-H2090) .

Flow Cytometry

Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience, Transcription

Immunogen affinity purified.

Liquid

Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells.

1. Chen, C.-H., Howng, S.-L., Cheng, T.-S., Chou, M.-H., Huang, C.-Y., Hong, Y.-R. Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle. Biochem. Biophys. Res. Commun. 308: 975-983, 2003. 2. Chou, C. H., Loh, J. K., Yang, M. C., Lin, C. C., Hong, M. C., Cho, C. L., Chou, A. K., Wang, C. H., Lieu, A. S., Howng, S. L., Hsu, C. M., Hong, Y. R. AIBp regulates mitotic entry and mitotic spindle assembly by controlling activation of both Aurora-A and Plk1. Cell Cycle 14: 2764-2776, 2015. 3. Dauber, A., LaFranchi, S. H., Maliga, Z., Lui, J. C., Moon, J. E., McDeed, C., Henke, K., Zonana, J., Kingman, G. A., Pers, T. H., Baron, J., Rosenfeld, R. G., Hirschhorn, J. N., Harris, M. P., Hwa, V. Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein. J. Clin. Endocr. Metab. 97: E2140-E2151, 2012. Note: Electronic Article.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Endoglin

Membrane; Single-pass type I membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.