Anti-NLRP9 Antibody Picoband® 31.0550 Vervoeging

The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD) . This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5.

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

NLRP9

338321

Q7RTR0

Human

No cross-reactivity with other proteins

E.coli-derived human NLRP9 recombinant protein (Position: H118-H746) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. Inohara, N., Nunez, G. NODs: intracellular proteins involved in inflammation and apoptosis. Nature Rev. Immun. 3: 371-382, 2003. 2. Tschopp, J., Martinon, F., Burns, K. NALPs: a novel protein family involved in inflammation. Nature Rev. Molec. Cell Biol. 4: 95-104, 2003. 3. Zhu, S., Ding, S., Wang, P., Wei, Z., Pan, W., Palm, N. W., Yang, Y., Yu, H., Li, H.-B., Wang, G., Lei, X., de Zoete, M. R., and 13 others. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 546: 667-670, 2017.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

RNA-binding protein 47

Nucleus .

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.