Anti-NLRX1 Antibody Picoband® fluoro488 Vervoeging

NLRX1 or NLR family member X1, short for nucleotide-binding oligomerization domain, leucine rich repeat containing X1 is a protein that in humans is encoded by the NLRX1 gene. The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene.

Transmembrane protein 107; TMEM107; DC20, UNQ638/PRO1268

NLRX1

79671

Q86UT6

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human NLRX1 recombinant protein (Position: R98-E874) .

Ubiquitous. .

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity) . .

1. Guo, H., Konig, R., Deng, M., Riess, M., Mo, J., Zhang, L., Petrucelli, A., Yoh, S. M., Barefoot, B., Samo, M., Sempowski, G. D., Zhang, A., and 14 others. NLRX1 sequesters STING to negatively regulate the interferon response, thereby facilitating the replication of HIV-1 and DNA viruses. Cell Host Microbe 19: 515-528, 2016. 2. Inohara, N., Chamaillard, M., McDonald, C., Nunez, G. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Ann. Rev. Biochem. 74: 355-383, 2005. 3. Leber, A., Hontecillas, R., Tubau-Juni, N., Zoccoli-Rodriguez, V., Hulver, M., McMillan, R., Eden, K., Allen, I. C., Bassaganya-Riera, J. NLRX1 regulates effector and metabolic functions of CD4+ T cells. J. Immun. 198: 2260-2268, 2017.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

15503 MW

6

Transmembrane protein 107

Membrane ; Multi-pass membrane protein .

Transmembrane protein 107

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.