Anti-NOP58 Antibody Picoband® 31.0550 Vervoeging

Nucleolar protein 58 is a protein that in humans is encoded by the NOP58 gene. The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs.

Matrix metalloproteinase-16; MMP-16; 3.4.24.-; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP; MMP16; MMPX2

NOP58

51602

Q9Y2X3

Human

No cross-reactivity with other proteins.

E.coli-derived human NOP58 recombinant protein (Position: K30-K450) .

Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

Flow Cytometry

Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes

Immunogen affinity purified.

Liquid

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/8/2016. 2. Lyman, S. K., Gerace, L., Baserga, S. J. Human Nop5/Nop58 is a component common to the box C/D small nucleolar ribonucleoproteins. RNA 5: 1597-1604, 1999. 3. Nelson, S. A., Santora, K. E., LaRochelle, W. J. Isolation and characterization of a novel PDGF-induced human gene. Gene 253: 87-93, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39125 MW

6

Matrix metallopeptidase 16

Isoform Long: Cell membrane ; Localized at the cell surface of melanoma cells.

RNA-binding protein Musashi homolog 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.