Anti-NPLOC4 Antilichaam

Boster Bio Anti-NPLOC4 Antibody catalog # A08476. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Nuclear protein localization protein 4 homolog; Protein NPL4; NPLOC4; KIAA1499, NPL4

NPLOC4

Q8TAT6

Human, Mouse, Rat

Recombinant fusion protein of human NPLOC4 (NP_060391.2) .

Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.

WB, ICC, IF

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

1 mg/mL

Liquid

The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) . Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729) .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A08476

68120 MW

Nuclear protein localization protein 4 homolog

Cytoplasm, cytosol

Nuclear protein localization protein 4 homolog

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2