Anti-NPRL2 Antibody Picoband® fluoro488 Vervoeging

Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene. Enables GTPase activator activity. Involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and negative regulation of kinase activity. Part of GATOR1 complex. Is active in lysosomal membrane. Implicated in familial focal epilepsy with variable foci 2.

NPRL2; TUSC4; GATOR complex protein NPRL2; Gene 21 protein; G21 protein; Nitrogen permease regulator 2-like protein; NPR2-like protein; Tumor suppressor candidate 4

NPRL2

10641

Q8WTW4

Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human NPRL2 recombinant protein (Position: D90-K380) . Human NPRL2 shares 98.3% amino acid (aa) sequence identity with mouse NPRL2.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Bar-Peled, L., Chantranupong, L., Cherniack, A. D., Chen, W. W., Ottina, K. A., Grabiner, B. C., Spear, E. D., Carter, S. L., Meyerson, M., Sabatini, D. M. A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 340: 1100-1106, 2013. 2. Gu, X., Orozco, J. M., Saxton, R. A., Condon, K. J., Liu, G. Y., Krawczyk, P. A., Scaria, S. M., Harper, J. W., Gygi, S. P., Sabatini, D. M. SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Science 358: 813-818, 2017. 3. Lerman, M. I., Minna, J. D. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. Cancer Res. 60: 6116-6133, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

44 kDa

6

NPR2 like, GATOR1 complex subunit

GATOR1 complex protein NPRL2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.