Anti-NR2C2 Antibody Picoband® fluoro488 Vervoeging

Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene. This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Platelet basic protein; PBP; C-X-C motif chemokine 7; Leukocyte-derived growth factor; LDGF; Macrophage-derived growth factor; MDGF; Small-inducible cytokine B7; PPBP; CTAP3; CXCL7; SCYB7; TGB1; THBGB1; NAP-2

NR2C2

7182

P49116

Human, Monkey, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human NR2C2 recombinant protein (Position: R7-L596) .

Flow Cytometry

Cardiovascular, Chemokines, Immunology, Innate Immunity, Platelets

Immunogen affinity purified.

Liquid

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2 (73), NAP-2 (74), NAP-2 (1-66), and most potent NAP-2 (1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III (1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.

1. Chang, C., da Silva, S. L., Ideta, R., Lee, Y., Yeh, S., Burbach, J. P. H. Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. Proc. Nat. Acad. Sci. 91: 6040-6044, 1994. 2. Chang, C., Kokontis, J., Acakpo-Satchivi, L., Liao, S., Takeda, H., Chang, Y. Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains. Biochem. Biophys. Res. Commun. 165: 735-741, 1989. 3. Chen, Y.-T., Collins, L. L., Uno, H., Chang, C. Deficits in motor coordination with aberrant cerebellar development in mice lacking testicular orphan nuclear receptor 4. Molec. Cell. Biol. 25: 2722-2732, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

12252 MW

6

Neutrophil-activating peptide 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.