Anti-NR5A2 Antibody Picoband® fluoro550 Vervoeging

NR5A2 (nuclear receptor subfamily 5, group A, member 2) also known as liver receptor homolog-1 (LRH-1) is a protein that in humans is encoded by the NR5A2 gene. LRH-1 is a member of the nuclear receptor family of intracellulartranscription factors. LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis andsteroidogenesis. LRH-1 is important for maintaining pluripotence of stem cells during embryonic development. Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.

Forkhead box protein P2; CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein; FOXP2; CAGH44, TNRC10

NR5A2

2494

O00482

Human

No cross-reactivity with other proteins.

E.coli-derived human NR5A2 recombinant protein (Position: K192-A508) .

Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. .

Flow Cytometry

Epigenetics and Nuclear Signaling, Forkhead Box, Transcription

Immunogen affinity purified.

Liquid

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

1. Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., Maloney, P. R., Willson, T. M., Kliewer, S. A. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Molec. Cell 6: 517-526, 2000. 2. Gu, P.; Goodwin, B.; Chung, A. C. -K.; Xu, X.; Wheeler, D. A.; Price, R. R.; Galardi, C.; Peng, L.; Latour, A. M.; Koller, B. H.; Gossen, J.; Kliewer, S. A.; Cooney, A. J. (2005) . Orphan Nuclear Receptor LRH-1 is Required to Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development. Molecular and Cellular Biology 25 (9) : 3492–3505.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

79919 MW

6

Forkhead box protein P2

Nucleus .

Protein NDRG1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.