Anti-NRBF2 Antibody Picoband® fluoro550 Vervoeging

Nuclear receptor-binding factor 2 is a protein that in humans is encoded by the NRBF2 gene. Involved in autophagy. Located in cytoplasm. Colocalizes with phosphatidylinositol 3-kinase complex, class III.

Tudor domain-containing protein 3; TDRD3

NRBF2

29982

Q96F24

Human

No cross-reactivity with other proteins.

E.coli-derived human NRBF2 recombinant protein (Position: M1-N287) .

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Flow Cytometry

Adaptive Immunity, B Cells, Immunoglobulins, Immunology

Immunogen affinity purified.

Liquid

Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

1. Darabi, H., McCue, K., Beesley, J., Michailidou, K., Nord, S., Kar, S., Humphreys, K., Thompson, D., Ghoussaini, M., Bolla, M. K., Dennis, J., Wang, Q., and 119 others. Polymorphisms in a putative enhancer at the 10q21.2 breast cancer risk locus regulate NRBF2 expression. Am. J. Hum. Genet. 97: 22-34, 2015. 2. Flores, A. M., Li, L., Aneskievich, B. J. Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator. J. Invest. Derm. 123: 1092-1101, 2004. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 7/22/2015.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Tudor domain containing 3

Nucleus. Cytoplasm.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.