Anti-NRD1/NRDC Antilichaam Picoband® 31.0550 Vervoeging

This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.

Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1; p38; AHSA1; C14orf3; HSPC322

NRDC

4898

O43847

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human NRD1/NRDC recombinant protein (Position: K427-R967) .

Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.

Flow Cytometry

Chaperones, Golgi Proteins, Protein Trafficking, Signal Transduction

Immunogen affinity purified.

Liquid

Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360) .

1. Fumagalli, P., Accarino, M., Egeo, A., Scartezzini, P., Rappazzo, G., Pizzuti, A., Avvantaggiato, V., Simeone, A., Arrigo, G., Zuffardi, O., Ottolenghi, S., Taramelli, R. Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. Genomics 47: 238-245, 1998. 2. Hospital, V., Prat, A., Joulie, C., Cherif, D., Day, R., Cohen, P. Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family. Biochem. J. 327: 773-779, 1997. 3. Ohno, M., Hiraoka, Y., Matsuoka, T., Tomimoto, H., Takao, K., Miyakawa, T., Oshima, N., Kiyonari, H., Kimura, T., Kita, T., Nishi, E. Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nature Neurosci. 12: 1506-1513, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

132 kDa

6

Activator of HSP90 ATPase activity 1

Cytoplasm, cytosol.

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.