Anti-NRG2 Antibody Picoband® fluoro594 Vervoeging

Neuregulin 2, also known as NRG2, DON1 or NTAK, is a protein that in humans is encoded by the NRG2 gene. Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. The NRG2 gene is mapped to 5q31.2. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The human NRG2 gene contains 12 exons and the mouse Nrg2 gene contains 12 exons and spans about 180 kb. The NRG2 genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. In particular, the neuregulin-ERBB signaling pathways play crucial roles in regulating the proliferation and differentiation of Schwann cells, the myelin-forming cells in the peripheral nervous system.

Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2; Neuregulin-2; NRG-2; Divergent of neuregulin-1; DON-1; Neural- and thymus-derived activator for ERBB kinases; NTAK; NRG2; NTAK

NRG2

9542

O14511

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human NRG2, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

Restricted to the cerebellum in the adult.

Flow Cytometry

Intracellular Signaling, Kinases, Neuroscience, Neurotransmission, Protein Phosphorylation, Signal Transduction, Tyrosine Kinases

Immunogen affinity purified.

Liquid

Ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

1. Britto, J. M., Lukehurst, S., Weller, R., Fraser, C., Qiu, Y., Hertzog, P., Busfield, S. J. Generation and characterization of neuregulin-2-deficient mice. Molec. Cell. Biol. 24: 8221-8226, 2004. 2. Burden, S., Yarden, Y. Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron 18: 847-855, 1997. 3. Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997) . Ligands for ErbB-family receptors encoded by a neuregulin-like gene.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

91679 MW

No cross reactivity with other proteins.

6

Pro-neuregulin-2, membrane-bound isoform

Pro-neuregulin-2, membrane-bound isoform: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .

Belongs to the neuregulin family.

Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.