Anti-NSL1 Antibody Picoband® 0,00647 Vervoeging

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene. This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X.

NSL1; C1orf48; DC31; DC8; MIS14; Kinetochore-associated protein NSL1 homolog

NSL1

25936

Q96IY1

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human NSL1 recombinant protein (Position: M1-K231) . Human NSL1 shares 68.8% amino acid (aa) sequence identity with mouse NSL1.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Obuse, C., Iwasaki, O., Kiyomitsu, T., Goshima, G., Toyoda, Y., Yanagida, M. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nature Cell Biol. 6: 1135-1141, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

32 kDa

6

NSL1 component of MIS12 kinetochore complex

Kinetochore-associated protein NSL1 homolog

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.